AffinityDNA Dog Multidrug Resistance 1 MDR1 DNA Test Kit – Home Sample Collection Kit for 1 Canine – Dog MDR1 Testing Kits from

Description

Multidrug Resistance 1 is inherited as an autosomal incomplete dominant disease. The MDR1 gene codes for the production of a protein known as p-glycoprotein. P-glycoprotein acts as a pump that removes certain drugs and toxins from the body. A mutation in the ABCB1 gene associated with MDR1 prohibits P-glycoprotein’s ability to limit absorption, distribution, and excretion of drugs and allows higher levels of drugs to enter the brain.
Dogs only need to inherit one copy of the MDR1 mutation to be at risk for sensitivity to certain drugs. Dogs with two copies of the MDR1 mutation can have more severe reactions such as excess salivation, tremors, anorexia, blindness and possibly death.
MDR1 affected dogs are at risk of developing neurologic symptoms from several common drugs and you should inform your veterinarian if your dog is a MDR1-carrier or MDR1-affected so they can adjust dosage or provide an alternative medication.
The DNA test is an accurate, convenient, and affordable tool to help breeders avoid producing Multidrug Resistance 1 carrier and affected offspring and significantly reduce the gene frequency in future generations.
This test is available for many dog breeds (see images for full list).
The results confirm 1 of the 3 possible genotypes for the tested dog:
CLEAR (those having two genes from their parents that are mutation free and will not be affected by MDR1).
CARRIER (those having one normal copy of the MDR1 gene, and one mutation. This means that the dog has an increased risk of drug sensitivity).
AFFECTED (those having two copies of the mutated MDR1 gene from their parents and are at risk of adverse drug reactions).

The DNA Sample Collection Kit Contains – 4 x sterile mouth swabs (all 4 for 1 dog), step-by-step sample collection instructions, registration form and return envelope.